There are multiple factors currently limiting the discovery and approval of new medicines. The low-hanging fruit has already been picked, and regulatory constraints have tightened, requiring new drugs to show an increased level of efficacy and safety while also displaying significant differentiation from treatments already available. In addition payers are beginning to demand that new, pricier drugs demonstrate that they’re worth it. At the same time the race to be first approved for novel therapies puts an even greater focus on the need to be more efficient in clinical development. These factors have created an urgent need to get more ROI from R&D.